Hydrocodone has to be one of the best drugs known to man. I had a very small prescription for my wisdom teeth and I instantly understood the opioid dependency problem.

It's all about your body chemistry. I'm a redhead; red hair is a result of a mutation in the preopiomelanocortin (POMC) system, so opioids work funny on us. I've had hydrocodone/acetaminophen(paracetamol) pills, and they felt like... taking acetaminophen. No euphoria, not even increased pain relief. I quit after one dose, because what was the point in making myself constipated?

I dunno man. My mom and dad were both smack heads. They both went through recovery but had substantial relapses. My mom was as ginger as they come but really couldn't get off the horse. Dad found solace in terminal alcoholism. So.. I dunno. Thoughts?

Booze doesn't work that way, and there are a lot of mutations that can cause gingerism - but the one I have, opioids don't do much of anything.

Never had the hard stuff and not inclined to try. But the oral ones might as well be cornstarch.