The Slay the Spire board game, which launched a kickstarter to ship next year, has a Tabletop Simulator version and has easily worked its way towards the top of my board game list, even before receiving the physical copy. In fact, it's the first game that's made me willing to tolerate TTS to play it, my board game group during the pandemic tried to do some TTS sessions but it always fell a little bit flat.

There's plenty of info out there about it so I'll avoid giving a detailed recap, but since it's a coop game and it feels best with 3-4 players, if folks are interested in trying it out, I'd be happy to host a session. E-mail is in my profile.