I met a physicist who had written a paper in the 1980s about a fusion reactor that used the high energy neutrons from D-T fusion to breed ²³³U from ²³²Th, around the time that people were losing interest in fast reactors. The reactor itself might not be a profitable source of energy directly, but the fuel it produces would be useful in thermal fission reactors.
Fusion will be attractive as a neutron source long before it is attractive as an energy source, in fact there are many kinds of neutron generators already in use that use fusion.
The waste from fusion will be different in character from fission. Unless you are trying to make TRU you are not going to have any transuranic waste. Most of the real danger from fission products is in isotopes of a few elements in a particular range of atomic number, particular Cs and I.
On the other hand, a D-T reactor is going to have a lot of T around and T is hard to contain since hydrogen likes to infiltrate between the atoms in metals. The flux of neutrons on the first wall is going to be absolutely brutal, how bad the activation is will depend on what exact materials you're using, but the difficulty of the situation is such that you might not have much of a choice.
