When it comes to hosted options, they are hands down the best. Worth pointing out that they also have integrated 2FA, if you're satisfied with first and second factor living in the same spot.
It is still 2 factor, breaching the password manager is a corner case that you can decide to cover or not. It seems like for critical accounts you should NOT. For derived accounts, it should be better than just a password.
For a "service based" password manager, sure. (It can prevent the service from ever handing over your encrypted database to an attacker.)
In a local password manager, it doesn't work like that. A challenge-response mechanism can help there, but the cost/benefit analysis looks pretty different there, IMO.
When it comes to hosted options, they are hands down the best. Worth pointing out that they also have integrated 2FA, if you're satisfied with first and second factor living in the same spot.
https://1password.com