Personally, it's the scoping that drives me nuts more than the weird version of dynamic typing (which is awful, but can be fixed). A lot of "pythonic" syntax is also very python-specific and hard to read if you aren't a python person. There is also the implicit type conversion and the runtime errors for things a linter or a compiler would catch in another language.

If you only work on <1000 line scripts, Python is a blast. If you work on projects with >1M LoC, it gets very hard to keep everything you need in your head if you want to understand code that other people have written.