Some industries including large subsets of the tech industry have become essentially zero-sum games.
It's almost impossible to make money in those industries because they have been monopolized.
If you happen to launch a software service in those industries, you will not be able to get any serious traffic from Google or social media because those platforms favor certain providers over others (e.g. US-based providers). Also you need to be careful of launching in an industry which is about to become monopolized.
So if you're not based in the US or you don't have many personal connections, you shouldn't dream too big; you need to find a niche which isn't going to be gate-kept.
You're insane if you don't launch in the US - even virtually. US is where the money is, US is where the market is, and US is where the only customers that matter are (unless you're selling to defence, gov or niche regional finance).
It makes acquisitions easier, it makes hiring easier, it makes marketing and sales easier and it makes billing easier.
Unless you want to bootstrap until you retire because it's a lifestyle business, then just do it where you are and chill - you are the 0.001%.
If you can name a global organisation that doesn't get the lion's share of revenue from US organisations, or doesn't make major purchasing decisions out of the US - feel free to correct me. If you're a startup, you should only be going after low-hanging fruit, and that's only your existing network, and in the US.
So if you're not based in the US or you don't have many personal connections, you shouldn't dream too big; you need to find a niche which isn't going to be gate-kept.