People who are overweight should not be accused of being similar to corporations that misallocate and overspend (i.e. fat corporation, bloated spending, etc.).
Anemic, impotent, bald, and on and on.
Language is abstract. Some conditions are generally disfavored. Referencing that disfavor abstractly can be meaningful.
Come now. At the root of all of this is an ableist, patronizing assumption: People with mental disabilities must have the language used around them carefully policed because they can't handle the implied disfavor and emotional harm that language may communicate via their own agency, not like the rest of us.
How would you define adult humor? Surely we have some latitude to be a little off color without being straight up racist, (blank)phobic, and vile? We aren’t kids, we have somewhat of a sophisticated ability to be at another level of sarcasm, humor and dark humor.