Would you be able to write more about dopamine agonists "screw[ing] some things up about you semi-permanently?"
I was on them for RLS for a while. I had even started taking L-DOPA, when pramipexole/ropinirole/gabapentin/etc. were negatively affecting my quality of life. However, the L-DOPA triggered some very, in-hindsight but unfortunately never during, terrible personality changes. One of which decided that it was prudent to keep upping my L-DOPA dosage, become a severe poly-substance abuser, and all-around just make a huge mess of my life.
I may also be recovering from nerve damage in my legs and feet from this escapade (either from the L-DOPA causing oxidative damage/receptor over-excitement and death -- or from the litany of other substances). I may have also unknowingly "semi-permanently" down-regulated my AAAH (?) enzymes, leading to effects I cannot even imagine.
I was on them for RLS for a while. I had even started taking L-DOPA, when pramipexole/ropinirole/gabapentin/etc. were negatively affecting my quality of life. However, the L-DOPA triggered some very, in-hindsight but unfortunately never during, terrible personality changes. One of which decided that it was prudent to keep upping my L-DOPA dosage, become a severe poly-substance abuser, and all-around just make a huge mess of my life.
I may also be recovering from nerve damage in my legs and feet from this escapade (either from the L-DOPA causing oxidative damage/receptor over-excitement and death -- or from the litany of other substances). I may have also unknowingly "semi-permanently" down-regulated my AAAH (?) enzymes, leading to effects I cannot even imagine.