The most accurate, currently used ICBMs can have a CEP ranging from 10 to 130 meters so they can probably be used that way. Most ICBMs also have a configurable "detonation" height, meaning they can probably be set low enough to severely damage a nuclear plant reactor containment building. Not sure if they are powerful enough to vaporize the fuel rods though.
But as you said, at that point, it wouldn't really matter anymore.
I'm told by ex-(Submarine Commander)s and ex-submariners that it's surprisingly accurate, and one even said that it's used in training. If you read it carefully enough you can plot the positions of the boats throughout.
Definitely better than the film, although the film is excellent.
Could I get submarine book recommendations please!!
Bewarned however, I've read (listened) to a good few already. ;)