How much art, science and deep, personal perspectives were lost due to abuse and death stemming from substance abuse? In case of certain substances (like alcohol) we have rather hard statistics about it's overal impact on physical and mental condition of society. Slow change from alcohol to safer alternatives (ex. cannabis) is probably one of the best trends in current times.
How many lives were saved or changed for the 'better' through the escape of, enjoyment of or numbing with drugs and alcohol? Who knows?
Perhaps if we think more like adults instead of infants we can try to understand complex issues better instead of reinforcing black and white stereotypes of the world or rehashing whatever our favourite source of ignorance tells us.