I use a keyboard similar to yours (Sofle V2) and I've found I don't really have a problem switching between them. I pretty regularly can type on both it, and my normal macbook keyboard without much thought given to it. Only occasionally do I feel myself trying to reach for a thumb button that isn't there and for the most part I can handle window switching fine. The switch from Mac to Windows which I do once a day is more frustrating as suddenly my copy paste key is one over from where it was.

However that switching is the reason I remain on qwerty, because I think at that point I'd find switching hard.