Kentucky is the UPS International Air Hub, nearly all UPS cargo flights go there. FedEx is Memphis, both because they are well positioned relative to the densest parts of the US population with the earliest delivery requirements.
I visited China in 2018, I live just outside of Anchorage.
First we flew to Seattle, and then after a layover, flew directly over Anchorage to Beijing via the great circle route. About 10 hrs and maybe 3800 miles into the journey, I was looking down at my home town.
Kentucky is the UPS International Air Hub, nearly all UPS cargo flights go there. FedEx is Memphis, both because they are well positioned relative to the densest parts of the US population with the earliest delivery requirements.