There is a difference in scale. For the research 23andme wants to do, they need to identify variants that occur in a significant part of the population (~1% or so). They need to do this because any potential drug/treatment would have to be developed for a big enough patient pool. Large population level genome studies like 1000 genomes and NIH All of Us studies are all aimed at finding those ~1% variants.
But if you’re looking for what is going on in an individual, then yes… SNP chip data isn’t as informative as whole genome (or exome) sequencing.
But if you’re looking for what is going on in an individual, then yes… SNP chip data isn’t as informative as whole genome (or exome) sequencing.