Nice point. By the way, IMO, some long-known and safe substances should also be given new tries in combination with the researched psychedelics. E.g. I believe piracetam is a great thing to take half an hour before you take MDMA - it may catalyse the effect (in a therapeutic setting especially as speaking boost is among its effects) and prevent hangover. It's not approved by the FDA but widely used in Europe and obviously (given a really huge base of empiric evidence) safe.