Well, first of all, an unequal food supply chain has generated survival diets close to civilization, spreading new diseases to the entire world (hi Covid!, next door to bird flu).
Second, there are droughts popping up all around the world, our fisheries are collapsing but our supply chain might be absorbing the problems of it until suddenly it doesn't anymore.
That is my deep worry -- that we are seeing the start of a generalized system collapse.