I've been using a Moonlander exclusively on my desktop since November 2020 while having no trouble continuing to use a Macbook Air or my old Acer laptop.
The differently placed modifier keys on the laptops screw me up infinitely more than going from an ortholinear split to a laptop and back.
I can second this - my main driver is a Dactyl-Manuform (ortholinear), and I have zero problems on any of the other four non-ortho keyboards that I use.
I also use Dvorak as my main layout and have no problems when going back to a QWERTY one.
I've also been using a Moonlander since late 2020 and going back to a laptop has been fine. The fact that on my two Lenovo laptops, the Ctrl and Fn keys are not in the same order (whoever thought this was a good idea?) is anecdotally also a much more frequent cause of issues.
With a programable mechanical kb you should be able to match the Mac layout. There are a few split versions that should have sufficient keys, especially if you're not using a ten-key frequently.
The differently placed modifier keys on the laptops screw me up infinitely more than going from an ortholinear split to a laptop and back.