\* among patients hospitalized with severe illness in one Wuhan hospital between...

criticaltinker · on Aug 27, 2021

Yes thank you. GPs comment is completely inaccurate, and the referenced study does not make any claims about natural infection, only about patients hospitalized with severe illness.

Multiple recent large scale studies have estimated an asymptomatic proportion lower bound of at least ~33% [1], and an upper bound of 65% (and even higher for young adults) [2]. This implies a significant proportion of people infected by SARS-COV-2 will not experience any noticeable symptoms.

Furthermore, there is strong evidence that infections and cases are massively under-reported (by 10x to 100x) [3][4], so it's exceedingly likely that such estimates are underestimates of the true asymptomatic rate.

[1] The Proportion of SARS-CoV-2 Infections That Are Asymptomatic https://www.acpjournals.org/doi/full/10.7326/M20-6976

[2] Estimating the asymptomatic proportion of SARS-CoV-2 infection in the general population: Analysis of nationwide serosurvey data in the Netherlands https://link.springer.com/article/10.1007/s10654-021-00768-y

[3] Evaluating the massive underreporting and undertesting of COVID-19 cases in multiple global epicenters https://www.sciencedirect.com/science/article/pii/S253104372...

[4] Undiagnosed SARS-CoV-2 seropositivity during the first 6 months of the COVID-19 pandemic in the United States https://stm.sciencemag.org/content/13/601/eabh3826