The basics work, however for example screen readers do not anounce context menus under Windows, treeviews are not providing all the information they could see (https://bugreports.qt.io/browse/QTBUG-81874?jql=text%20~%20%...), etc. But in the end, if you need somewhat more advanced widgets (tables etc.) and you do not want to implement the gui on each platform or use Electron or similar, you have no choice.