Denmark reports AZ's serious blood clotting issue as up to 1:40'000.
I will still get vaccinated with it if it's available in our country for me as I think the risk is worth it in my case. But if I was a woman under 60 and especially under 40 I would be hesitant to get vaccinated with AZ and probably wait for other vaccine.
"The Danish Health Authority said studies had shown a higher than expected frequency of blood clots following doses, affecting about one in 40,000 people."
It's a weird one isn't it - 1/40,000 but they only gave 150,000 doses out. This seems like the error bars on this would be huge - we've seen in the UK very few of these events with millions vaccinated which is pretty strange. Is there something different about Denmark and Britain at this time of year?
I've had the AZ vaccine 1st dose 3 weeks ago now and I keep getting very concerned by the ever changing picture; is it 1 in a million or 1 in 40000, or did these people have conditions that made this situation more likely... will we see an increase in the rate as we get more data too over the coming weeks a lot like we did with COVID.
All very unclear right now. I wish the case reports of all the people with blood clots were made available so everyone could review if they match the groups who have had the problems.
As to the difference, maybe they first vaccinated health professionals with AZ and UK mostly vaccinated older people with it, so different issues became apparent? It affects mostly younger women, so it would manifest pretty clearly with female nurses.
One thing I haven't seen discussed is that staff nurses, instrument nurses, etc. spend much more time standing up in a stationary position (not walking or sitting) compared with other healthcare workers in a hospital setting.
Everyone is jumping to focus on young females/genetics but it could really just be occupation related, most of these nurses will have their vacine shot on-site and continue their daily shift afterwards (where they stand orthostatic for several hours).
I can only speculate since I know next to nothing about that but AFAIK those thromboses are not in leg veins but in different parts of the body - in the brain (Cerebral venous sinus thrombosis), lungs (embolism) etc.
"Vaccination with ChAdOx1 nCov-19 can result in the rare development of immune thrombotic thrombocytopenia mediated by platelet-activating antibodies against PF4, which clinically mimics autoimmune heparin-induced thrombocytopenia."
I think I read 10 somewhere but as I’ve said in the sibling comment it’s hard to know if these were all weird cases like the one who died or if they fit a pattern at all.
I will still get vaccinated with it if it's available in our country for me as I think the risk is worth it in my case. But if I was a woman under 60 and especially under 40 I would be hesitant to get vaccinated with AZ and probably wait for other vaccine.