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Does anyone know how reusable the mRNA infrastructure is in the future for other mRNA based solutions or is this stuff more one-off for COVID?


It should be fully reusable for similar applications.

The mRNA production is basically 1:1 capacity. If a different application needed a different lipid some of the stuff might not be suitable.


In my understanding, the mRNA platform can be used for any application where you want to temporarily express a protein in the body. In the case of these COVID vaccines, it's being used to express the coronavirus spike protein, but Moderna is already using this technology for HIV, flu and others[0]. I believe the applications beyond vaccines are many, too.

[0] https://www.marketwatch.com/story/moderna-offers-update-on-v...


It’s pretty much the holy grail for vaccines. It delivers the spike protein via mRNA and the hardest part is the delivery which they’re ironing out with nanolipids (also Moderna biggest IP) during this COVID run. Though I’m an engineer so take everything at face value.


The vaccine only contains the (mRNA) blueprints for the spike protein that cells of the body will then produce themselves. The immune system then reacts to those.


Very. Moderna's main focus is (or was) oncology; specifically personalized cancer vaccines.


On both ends of the spectrum of mortality rates:

Common cold: https://pubmed.ncbi.nlm.nih.gov/23159882/.

Malaria: https://yaledailynews.com/blog/2021/03/12/yale-lab-develops-...


mRNA is a decade in the making, which is why they were able to target/isolate a COVID-19 vaccine is a very short time. Two weeks I believe, someone please correct me.


I think it was more like two days. Very quick.


To be fair, the previously published genome gave a big head start - not sure how long that took though.




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