At first I thought "not another one," but Dave has really done some great work. Simple, lightweight, and beautiful. Not to mention he provides a great set of media queries to aid with responsive designs and a handful of basic elements (forms, buttons, and a tab system). Definitely going to employ this for "quickie" projects or documentation pages.
It's "a collection of responsive designs". Some great examples in there.
Also: http://www.angrycreative.se/projekt/less-framework/ Another nice media query framework, though a bit more complicated.