It feels like some of these suggestions reduce the readability and maintainability of the TypeScript, as well as rail roading you into patterns that perhaps don't suit your architecture. Manually annotating return types of functions rather than letting them be inferred, and preferring interfaces to intersections for example.

I think I'll largely continue to write my TypeScript in the way that seems best to me using the syntax provided to me, and let MS hopefully optimise these issues under the hood over time.