Their underlying assumption is shown in, "Previous research has shown that the progression of Alzheimer’s disease is driven by a vicious cycle of the protein amyloid β (Aβ) inducing hyperactivity at the neuron level."
This is a widespread belief and has been the main target of attempted treatments for decades. Every one of which has failed. And therefore I predict that a drug trial based on this research will likewise fail.
So if that fails, what should we do instead?
See https://www.nature.com/articles/d41586-018-05719-4 for an overview of why it is reasonable that the root cause is infections and amyloid β is a symptom of our brains attempts to fight it off. Which explains why decades of drug trials aimed at disrupting the creation of amyloid β (which this does) have failed dismally.
As https://blogs.scientificamerican.com/observations/could-alzh... points out, treating people with the anti-herpes drug acyclovir was found to reduce the odds of getting Alzheimer's by 80%. Contrast this with the inability over many drug trials of any drugs aimed at amyloid β to demonstrate any effect on Alzheimer's at all.
As the old quote goes, "science progresses one funeral at a time". We're going to see ongoing research for a long time based on the idea that amyloid β is the cause of Alzheimer's. In the meantime if you have a family history of Alzheimer's, I would recommend getting a prescription for the only drug that has ever demonstrated any clinical success. Namely acyclovir. And start it before permanent damage has been done to your brain.
Their underlying assumption is shown in, "Previous research has shown that the progression of Alzheimer’s disease is driven by a vicious cycle of the protein amyloid β (Aβ) inducing hyperactivity at the neuron level."
This is a widespread belief and has been the main target of attempted treatments for decades. Every one of which has failed. And therefore I predict that a drug trial based on this research will likewise fail.
So if that fails, what should we do instead?
See https://www.nature.com/articles/d41586-018-05719-4 for an overview of why it is reasonable that the root cause is infections and amyloid β is a symptom of our brains attempts to fight it off. Which explains why decades of drug trials aimed at disrupting the creation of amyloid β (which this does) have failed dismally.
As https://blogs.scientificamerican.com/observations/could-alzh... points out, treating people with the anti-herpes drug acyclovir was found to reduce the odds of getting Alzheimer's by 80%. Contrast this with the inability over many drug trials of any drugs aimed at amyloid β to demonstrate any effect on Alzheimer's at all.
As the old quote goes, "science progresses one funeral at a time". We're going to see ongoing research for a long time based on the idea that amyloid β is the cause of Alzheimer's. In the meantime if you have a family history of Alzheimer's, I would recommend getting a prescription for the only drug that has ever demonstrated any clinical success. Namely acyclovir. And start it before permanent damage has been done to your brain.