It's been awhile since I've messed with a GUI in python, so I did quick image search to see just how ugly it is. And it actually looks very serviceable. A bit utilitarian, perhaps, but not too bad. I was expecting much worse, like the old Tk dialogs. And judging by the variety of examples I found, it can be themed to some degree. My only problem - and what has driven me to use web apps in the past - is the difficulties in bundling and distributing python apps.
Something I've learned in my old age is that merely ugly is still better than anything I'm likely to come up with myself. If something threatens to be interesting enough to distribute, the marketeers will never let me decide how it's going to look anyway. For the work that I do, not having to think about layout or aesthetics at all is a time saver with virtually no downside.
