I can commiserate with this attitude but still find myself disagreeing. I have worked in the type of role where I was expected to lead a transformational change when it seems like the incentives at every level are aligned against it.

I do personally feel an obligation to keep trying because if I didn't I'm not doing my job. Throwing up my hands in exasperation means I'm collecting a pay check just to keep the status quo. That makes me part of the problem as well as resigning myself to be miserable. I think we owe it to ourselves and the organization to move on if we get to that point.