The Firefox version has the ability to block third party scripts masked as first party ones through the use of CNAMEs. Chrome doesn't expose APIs to let extensions do it.
> The blocking ability of the webRequest API is still deprecated, and Google Chrome's limited matching algorithm will be the only one possible, and with limits dictated by Google employees.
Firefox + uBO + uMatrix will block everything you can reasonably block without making your internet life miserable in the other extreme (although uMatrix can be a pain sometimes).
While uMatrix may be a bit of a pain, once you have your basic rulset and whitelists setup it functions very well, and beyond that, it really helps you understand what makes the modern web so shitty, and helps you know which sites are part of that and which aren't, which I think is pretty invaluable. Like many things, it may take more upfront investment but it's worth it imho.
If I could force every webdev to browse their site with a fresh uMatrix install I would.