At 48KHz the setup can sustain 128-entries buffers, or <3ms. Sound travels at about 1ft per sec, so this is the equivalent of hearing an amp that is <3 feet afar. I cannot perceive the latency. The AmPlug I/O has a 3.5mm headphones port.

That sounds very cool! Which compute stick do you have, the Intel Atom Z8350? Also, have you experimented with ways to change effects on the fly?

I used an STK2M364CC. CPU usage never seems to go above 50%. Control is still a pain, but one way to change effects on the fly is to use rtpMIDI and TouchDAW on a phone.

Right on, thanks for sharing your knowledge on this!