I've answered to these points in another comment. But I'll emphasize, that I know (and presume you know) within some minimum epistemic bound^, that we can suffer pain and that arises from our neurological systems. It can't be known what other systems/substrates could experience qualia, and even if they have the outward markers of consciousness, they could be 'zombies'.

https://en.wikipedia.org/wiki/Philosophical_zombie

^ i.e., not in some adversarial simulation etc.