But this is the stack I often work with now:

- Postgres

- Django ORM

- Django REST Framework

- Auto-generated OpenAPI Typescript functions

- A Redux store

- My React app

In other words, four ORM-like non-relational frameworks stacked on top of each other between Postgres and my app.

A generic solution for "complex, possibly unanticipated questions" would need to work through all of those layers.