I'm in the process of trying to figure out where I'm going to be based next, leaning towards Puerto Rico (love the climate, friendly local population, easy/cheap/fast hop to family in New York, incredible tax incentives for people running businesses, sense of excitement/opportunity as the state rebuilds). 'Comparable opportunity' is relative - while an engineer here isn't as likely to earn a Bay Area salary, as a founder I think it's likely I could raise a decent round while based here (likely sourcing a lot of capital from Silicon Valley) while enjoying a comparably low cost of living and doing business. If I were trying to build the next Instagram I wouldn't do it here but there are so many businesses that need to be built here. I'm a firm believer you can find opportunity anywhere if you get creative. It's more fun to be a statistical outlier :)

I'm also in a position at the moment where I have relatively low overhead (no kids, good health) and realize that might not be the case for everyone, though I'd bet it's the case for many people who don't bother to take advantage of it.