A good combination is uBlock Origin and Nano Defender (both correctly configured, there are steps you can follow online). uBlock Origin does a good job of blocking most stuff, and Nano Defender does a good job of stopping sites from detecting you have blocked their adverts, thus stopping the website from displaying a "Hey, you have an AdBlock, we need adverts to keep this site free. Disable your AdBlock and refresh to view this content".
Am I the only one that likes the "Hey, you have an AdBlock" popups?
They come up and I spend a few seconds deciding if it's important to me to read what is behind it, and 95% of the time that answer is "no". Saves me a TON of time. :-)