I've been using Cookie AutoDelete[1] (Chrome Extension). This way I can happily 'agree' to all of these popups that are the new scourge of the internet, knowing that any Cookies they do set get auto deleted from my browser 15 seconds after I close the offending tab. You have to train it by white-listing the domains you want to keep cookies for (like *.ycombinator.com) but once that's done it just does its job, and I can surf knowing that I'm not being tracked (well, not as heavily as I would be NOT using it).

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[1] https://chrome.google.com/webstore/detail/cookie-autodelete/...