That doesn't seem like a great idea. Like, one time my wife was hospitalized and they called to tell me. I think I would have been upset with myself if I didn't receive that call because I had installed an app to kill all calls from numbers I didn't recognize.
I've certainly thought about it (if anyone wants to suggest one they use, feel free), but I'm always held back by wondering whether or not those apps aren't simply yet another phone-number harvesting operation selling to spammers. (The fact that it would initially seem irrational to target people who are going out of their way to block spam callers would first require the entire notion of spam calling to be rational to begin with.)
They don’t store your contacts in the cloud and access to contacts is even optional (though they won’t be able to block spoofed ‘neighbor’ calls if you don’t give access, but they can label them).
They also market themselves as focused on privacy and they charge a $2/month subscription.
I haven’t gotten a spam call since I’ve used them.