You also have to factor in the speed of a resilver and account for the chance of a failure during this at risk window.
A mirror can resilver much faster, and it doesn't significantly affect the vdev performance while doing so. A RAIDZ resilver after a disc replacement can take a significant amount of time, and degrade performance seriously as it thrashes every single disc in the vdev.
Allan Jude and Michael Lucas' books on ZFS have tables describing the tradeoffs of the different possible vdev layouts, and they are worth a read for anyone setting up ZFS storage.
The danger of loosing data on a RAID10 resilver is much higher than people expect. A 6x8TB RAID10 has a 47.3% chance of encountering a URE during a rebuild, which means data loss.
A 6x8TB RAID6 has a 0.0002% chance of a URE.
(Assuming URE rate of 10^-14, in reality this rate is lower)
A mirror can resilver much faster, and it doesn't significantly affect the vdev performance while doing so. A RAIDZ resilver after a disc replacement can take a significant amount of time, and degrade performance seriously as it thrashes every single disc in the vdev.
Allan Jude and Michael Lucas' books on ZFS have tables describing the tradeoffs of the different possible vdev layouts, and they are worth a read for anyone setting up ZFS storage.