That's an example of the breakage though. Apigee's cloud runs in only 2 specific AWS regions. So once you tie all these pieces together, you end up with a long path, with some functionality that should be closer to the end user.
Apigee's cloud runs in a lot more than two AWS regions today, not to mention GCP regions, and the whole product can be installed in your own datacenter. We also offer a "micro gateway" that lets the proxy component run anywhere and communicate with the rest of Apigee via an API. We'll be taking this hybrid mode further and the Istio integration is one of the things that will take advantage of that hybrid model.