Since I've been playing with NixOS, this project reminded me of https://github.com/LnL7/nix-darwin which lets you use a system-wide configuration.nix on OS X. Never tried it but it looks neat.
I actually use this, using it to replace my old ansible setup. I've got a lot of things I need to merge into there after more testing but yep its neat.
Not as great as the nixos version but every bit helps.