Having half the guys around you laid off [or about to be] is not what I would call "ticking along comfortably".
Twitter is not a 100 000 people company where there's a 300 people division being restructured. It's a major management failure that needs at least 50% of lay off. At this scale, it will reflect to the entire environment and all the employees.
1. Not lean enough. That's why today's news bumped their share price.
2. Not great at leveraging value into revenue. That's what an acquirer would do, ostensibly.
Plus, the specifics of the Disney/Google rumors are of dubious veracity. Don't put too much, er, stock into them.
You could argue that they've hit peak audience and that might be fair. A change in leadership would probably push Twitter into becoming a more aggressive on the acquisition front itself, too. Basically, a lot of untapped value and too much overhead.
First Disney wanted to buy them apperantly, then Google. Then they both pulled out for some reason, and they are laying people off like crazy.
I may be wrong but from the little research I just did it sure seems like things aren't great.