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> our bodies are designed to process a very wide variety of foods in a very robust manner

There are indications that various health conditions can impair glucose regulation, and those affected would tolerate less dietary carbohydrate than healthy people. I'm aware of two conditions, elevated cortisol [1] and elevated blood iron [2] (which can be caused by regular alcohol consumption, btw).

[1] http://www.ncbi.nlm.nih.gov/pubmed/11724664

[2] http://www.ncbi.nlm.nih.gov/pubmed/26618110

Also, type 1 diabetes of course.



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