I know that capstone, keystone and unicorn are marketed to the "security community" but these projects are some of the most promising I've seen for programming in general, e.g., for the few people who still might want to write small, simple (and fast) programs that run on multiple architectures.
https://news.ycombinator.com/item?id=9751312
https://news.ycombinator.com/item?id=10021259