I did look around for known brotli+Firefox+nginx issues, but the only one that comes up is https://bugzilla.mozilla.org/show_bug.cgi?id=1215724 which was fixed in shipping Firefox months ago, so I'm assuming that's not the one you're talking about.
Sure, there is no official bug for this. The only way to see it is to check the dates when the new API was applied - its far too late after releasing versions already supporting brotli, but this commit was not backported anywhere so in a real life, its broken in FF. Just get an nginx, nginx brotli module from google and use FF 45. Good luck :)
Ah, looks like the part of bug 1242904 that was backported is just the security fix, not the entire library version update and the version update is in 46. So what you could be seeing is something like https://bugzilla.mozilla.org/show_bug.cgi?id=1254411
Of course the version update wasn't supposed to change the on-the-wire behavior... or so the library authors claimed. :(