That remains to be seen. I'm doing some pretty hardcore video encoding and processing that will use and extend some existing C libraries. I was tempted to just use the FFI to call them from Ruby (which I still may end up doing), but I figured that this is a great chance to test-drive D.
Compilation of your applications to binary for one. Also, it enables you to do the bit twiddling necessary to write device drivers and other lovely systems programming things. Maybe we'll see a better scripting language VM in D one of these days?