Zero is by the Replicache team and they are really nice guys. I've interacted with Aaron Boodman quite a bit in their Discord and he was very responsive and helpful, and took a lot of my comments into consideration in improving the product. It's a very hot space which IMO will revolutionize how we build GUIs IMO. Replicache is a bit hard to grasp at first but the nice thing is you bring your own DB (vs. use a service). I think this project needs more recognition. I would hate to see them fade just because they don't have the fancy backers like YC and the usual crowd. If they keep at it they might prevail since VC-backed startups like InstantDB tend to sell out and flame out.
It's cool to see some progress on aural migraines.
In the past I tried zolmitriptans for it but they don't do much, same with milder pain killers.
My migraines started at 20, two decades ago. I remember the first one like it was yesterday. I was studying CS and was coding on a dark-mode CRT monitor with a big fat window reflection on the screen.
It always happen the same way, with the characteristic jiggles, some kind of colorful, moving patterns of light that start in the center of my vision, slowly expanding to my entire field of view, making me temporarily blind. Then 30 mns after the onset of that, gone. 30 more minutes and the headache + strong nausea start, and immense fatigue. At that point I'm out of commission for a good 12h. Meaning I better be close to my bed, in total darkness.
It really sucks. I used to have them every 3 months on the dot, like on a timer. As I'm getting older I'm having less and less of them, going about a year without one. And they are a lot milder now. I have a lot less of the jiggles, no nausea and the headache is not so bad. I'm still fatigued but usually recover the same day. I consider myself lucky.
It seems to run in my family.
I've tried finding a trigger for the migraines but I have no clue. I used to associate them with bright lights as there is usually a bright light present when they happen, but it needs some other element. Stress and fatigue appear to be factors, as are tanins contained in red wine and beer. But sometimes none of these elements were present.
I have a personal non-scientific theory that serotonin levels play a role. High levels like I think I had when I was younger tend to trigger migraines. As I'm getting older and grumpier, I probably have low serotonin and less migraines...
Same, with aura, but without bad headache symptoms beyond a 3/10 on the pain scale. I use to have them monthly, almost on the dot. Unrelated to them, I started taking Magnesium supplements and now rarely ever have aura migraines. Kinda crazy how well it worked for me. Also could never really figure out the “precipitating factors” but bright light was almost always the direct trigger.
Thanks for sharing. I have the same “bright lights” hypothesis. If I see something bright I close my eyes until it feels like it’s passed. Seems to work, but who knows until I get my next one.
I’m also realizing in my late-30s that I have at least some form of dyslexia - I used to think Ambien made me hallucinate letters dancing on the page, but it’s my eye muscles and happens most when I’m tired.
Thank you. I would love to build something to make trials easier to find by the patients themselves, so you don't have to wait for the bureaucracy to kick in.
It sounds great and motivating, but what was your field? I feel doctors to be less than enthusiastic about engaging with people outside of their circle, especially if I ask for help about doing a startup. It's weird but I feel like a lot of them see you as a competitor somehow.
Heck, even in 2005 Snake was all I had on my TI-84 Plus. (Not the CE, just the plain old 1-bit display version.)
And it was a version of Snake that I’d written myself, in TI-BASIC and I used some kind of matrix to store the segments of the snake and when the snake grew in length the operations to move the snake around took more and more time. Until eventually it crashed.
It was, admittedly not the greatest Snake game ever. It may even have been one of the worst ever. But it my Snake and that made it okay
I feel bad that you didn't know about https://www.ticalc.org/ . Kids in my class would have loved to have a TI-89 instead of a TI-83, since there were so many better games for it.
There were some great games for the TI-85 (and later the TI-83) written in Z80 assembly. Certainly things much better than snake. Someone needed a PC link cable to get it on, but then you could send from one calculator to another with just the link cable included in the box. None would have worked on the 92 or 89 which used a different CPU.
I've actually thought of doing IT services for clinics as a means to get a foot in the door. That's some seriously deep undercover stuff... Very time consuming (could be worth it regardless). Were you getting paid for the IT services?
