I am still amazed the DoD will work with this guy. Yes, there are thousands of people at Space X, many of them former government employees that are well (and still) respected by their colleagues on civil/military side, but the latitude this guy gets...
The Bolt has been sold in the US for years - prior to this supply chain nonsense, you could easily buy a Bolt in the Midwest for low ~30k USD ish, new.
Bolt sales were very low. Then came the fire recall and supply chain issues. The mid cycle refresh Bolt is now in production but dealers are asking $37K.
Yep, you can use up to four displays in total. That includes the internal display, so using four external monitors would mean turning off the internal one.
What are the limits for refresh rate and resolution? Also I assume DP/HDMI extension ports are done via USB-C, right? May direct connections to USB-C monitor help?
The one compound I've used (on and off, for maybe a few weeks at a time over the past 18 years) intermittently is Clonazepam. Recently however I don't find the dosage to be very effective, and reading the literature, upping benzo dosage has a high risk of increased dependency. I'd like to avoid that.
I happened to randomly start Googling about Lithium and stumbled upon Lithium Orotate, which is sold as a supplement pretty much everywhere. There's a little bit of literature on Pubmed, but not much.
I take this exact brand and it is really great. just be careful if you stack with SSRIs. if I take a bit too much I started getting headaches/serotonin syndrome-esque effects. I stepped down to 2.5mg since I take some prescription meds but if you're vanilla 5mg is great to start. For me it does help relieve anxiety and boost my mood a bit. If you have a NY Times subscription or free article viewing you might also be interested in the article "Should we all take a bit of lithium?" which inspired me to try it. Here is an article with some info on dosing from a practicing doctor. https://www.chandramd.com/blog/low-dose-lithium-supplements
The problem with self-medicating lithium is that doses low enough to be harmless were not shown to be effective, and doses proven to be effective are too close to dangerous. The only way to get the dosage right is very careful blood testing.
I have a bipolar diagnosis but with medication I've been symptom free for over 5 years now. For the past two years I've been taking 5mg Lithium Orotate nightly as a supplement to my main medication Lamotrigine [1]. I started taking the Lithium as a prophylactic against dementia. Research has shown that a history of bipolar disorder is associated with significantly higher dementia risk [2-3]. Low-dose lithium has shown promise as being preventative against the progression of dementia [4].
After starting the Lithium Orotate I noticed some subjective improvements in mental clarity and mood within a couple weeks. The effect is very small though and not comparable to that of my main medication. Although it's possible that I'm only experiencing the placebo effect, I suspect that the Lithium actually is helping somewhat.
The 5mg dose in most commercially available Lithium Orotate supplements is a couple orders of magnitude less than the doses typically used to treat bipolar, but I think it would still be good idea to bring it up with a doctor. Also, try to manage your expectations. It's probably not going to change your life all at once, but you may notice some small subjective benefits over the longer term, and the research on low doses of lithium being partially preventative against dementia seems pretty solid.
I highly recommend not using lithium without medical supervision. All of the bipolar people I know have significant side-effects from it. You also need to be careful with hydration because lithium toxicity is dangerous. If you get confusion as a side-effect of toxicity, you become less able to recognize what is happening.
From my own experiences with atypical anti-psychotics, getting dehydrated or running low on carbohydrates can affect my motor control severely enough that I can't drive. (I always have water and energy bars on me.) It resolves within an hour after rehydrating.
Interactions with other medication or supplements can also be dangerous.
I can't say anything about low-dose lithium so I'm sorry if this is out of scope.
I did however take 600mg daily of Lithium Carbonate for a long time and it really helped me with my anxiety, and, importantly, it reduced my suicidal thoughts/self harm urges to basically zero from multiple times a day. This isn't as low as the doses people seem to use with Orotate, but it's still "subclinical".
I’ve known people that took lithium for bipolar. It’s not a drug I’d recommend taking without professional supervision. Its side effects can include personality disassociation, weight gain, and memory loss. The people that I knew fought tooth and nail to get off it.
Obviously, the effects will differ between people, but best to go into things with your eyes open and a professional to supervise things.
As you likely know, but some people replying to you seemingly don’t- lithium orotate is not the same as prescription lithium (carbonate? It’s been a while).
Takes more of the latter form to be effective, and lithium toxicity is no joke- it’s landed a family member (who’s been on it for decades) in the ER multiple times.
Lithium orotate is safe at the doses on the label of otc supplements.
In my experience if has a subtle but distinct effect in terms of reducing anxiety. Particularly if taken with water on an empty stomach. Can’t speak to its effect on bipolar type issues.
Plex Systems and Duo Security are the only two software of companies of relevance/size - both were bought within the last two years, by Rockwell Automation and Cisco respectively (both for $2 billion-ish). The metro Detroit/Ann Arbor startup scene is tiny. OneStream will probably have an exit north of $2 billion in the next two years.
Tens of thousands of jobs were created by FCA/Stellantis with the renovation of Sterling Heights Assembly Plant for Ram 1500 Production, the brand new $1.6 billion plant on Connor and Jefferson (which builds Grand Cherokee L (WL75) and Grand Cherokee (WL74) in Detroit across the street from Jefferson North (which still builds WD/WK2), and the GM renovation of Hamtramck (Factory Zero) for Hummer EV/Silverado 1500 EV/commercial EV VAN production.
Detroit's economy is still 95% automotive. Those four plants I referenced were huge positive developments for the local economy - SHAP, JNAP1, JNAP2, and Hamtramck are the heart of the working class economy in Detroit, providing good union jobs building high margin products, along with the suppliers that feed those plants.
The brain drain problem is very real. I graduated the University of Michigan in 2008 and the majority of my colleagues moved out of state. I can’t say I blame them. A good number have been successful at FAANG type companies or startups and seem relatively better than us who stayed in the state. The firms in Michigan just can’t compete with the total compensation you can get elsewhere. Most of the positions here are auto related still. The auto industry is cyclical and booms and busts.
Both Ann Arbor and Detroit have special events trying to lure back expatriates. Wish East Lansing did something similar but afraid we lack the startup jobs to make it worthwhile.
What Lansing does do is have social events trying to convince junior and seniors at MSU to stay locally and they've had some success with it.
I've personally tried to get several MSU alums Valley startups to outsource customer service jobs to East Lansing. The salaries they pay for those positions make it a struggle to live in SF but would be a fair wage in Michigan. I haven't had any success yet but I won't stop trying ;<).
I worked at two FAANGs then moved to Michigan about two years ago, just outside of Ann Arbor. I get contacted by a decent number of recruiters but I'd estimate only about 5-10% of them represent companies with a Michigan presence.
This. I've worked in the New York metro area for my entire working career, and non-competes are one reason why California will always, always win when it comes to fostering startups. From what I can tell, no other state has made them illegal, and none ever will because they're in the interest of employers.
Washington has it, but Microsoft and Amazon were able to water it down so that it excludes higher compensated employees ($107k salary for 2022, which basically excludes people in tech/medicine/law/engineering). Foolish decision by WA legislators, especially when they are in prime position to poach business in the same time zone as CA with only a nominal state income tax.
Out of curiosity, how do these non-competes work with remote work situations? Are they applicable to the state the business is in or the state the worker is in? Is this one of the reasons so many software companies are pushing to get coders back in the office, just to get rid of these little legal questions?
Good question. Seems like it could get hairy. I would have assumed the employee’s state of residence takes precedence, but then there is this case where CA courts upheld a non compete that was entered into in MI before the employee moved to CA:
I'd emphasize "one reason" and de-emphasize "always" :)
The site linked above likes to throw cold water on the idea that non-competes are bad for workers, startups, etc (e.g., ND and OK aren't famous for their tech industries), see blog posts at https://faircompetitionlaw.com/ ... my bias is the other way (particularly enjoying https://ssrn.com/abstract=2517604), but the evidence is complex. Fortunately the aforementioned changes should generate new evidence.
I wouldn’t cite Compuware as an example of a successful Michigan based tech company. However, some products it created, such as Dynatrace, are still around and profitable.
No one knows right now, but we will know more over time. I guess we can take comfort in that a lot of people are in the same boat. I would like to better understand how/why mRNA vaccines can't/won't eventually turn into a dangerous prion.
I am genuinely confused as to why there seems to be more side effects/issues with the 'traditional' J&J vaccine vs. the mRNA Moderna/Pfizer vaccines. I would have thought the opposite to have been true.
But then again the Sputnik vaccine seems to be doing ok? So maybe it's just the J&J formulation. Who knows though, the peer reviewed data for this hasn't had much time to go through rigorous scrutiny.
Prions are proteins, so that's not much of a risk with the mRNA vaccines. But I do get your general point. As to why J&J seems to have more side-effects, its hard to tell. More than the peer-review step (which is attacked all the time), my sense is that the clot risk is so rare that the number of participants needed to observe enough clots was much much larger than the number of Phase 3 trial participants.
As for the Sputnik vaccine (and the Sinovac one in China), sampling rare events such as these and reporting them is a function of how many people have been given the vaccine + the amount of transparency of the authorities in the countries administering these vaccines.
> I would like to better understand how/why mRNA vaccines can't/won't eventually turn into a dangerous prion.
Why would it? A prion is a specific protein, why would this specific mRNA molecule, which only exists in our body for hours, cause that specific protein expression, when we have hundreds of thousands of other mRNA molecules per cell all similarly experiencing their own self destruction?
You're right, I may have been too dismissive, and you're right, science is about curiosity, but the "just asking questions" approach is a way to demolish perfectly good science. You can't prove a negative, and so throwing doubt after doubt at something is a good way to discredit a perfectly valid point because eventually you run out of answers. That's why I asked why they had that belief.
The user that asked the question didn't further engage, they just threw in some doubt and walked away. That doesn't feel like scientific curiosity. That feels like pot stirring.
