Hacker News new | past | comments | ask | show | jobs | submit | dtawfik1's comments login

Pre-diabetes undoubtedly leads to impaired glucose metabolism in neuronal cells.


You'd find this pre-print interesting: https://pubmed.ncbi.nlm.nih.gov/36973715/


Part of the adaptation that enables a higher VO2 Max


The closest thing to acarbose would be a metformin analog berberine, but it doesn't have the gut microbiota remodeling benefits. In terms of rapamycin, it's probably not a supplement but multiday fasting.


That's doable. I already use Berberine, 1.5G/day and I do prolonged fasting but I've not been consistent about doing 5day-FMD, so it seems that is something I need to fix. Thanks for the reply!


I am glad you enjoyed it. I think Tim Ferris is a thoughtful person, but I think people have put too much attention on the hacking part of this particular book, and not enough attention on building mastery.


I agree that he is thoughtful. His work on PTSD and psychedelics is interesting.


I'm glad you enjoyed it. It's my wife's essay, and it helped me make sense of the randomness of what happened.


Please tell her, thank you for writing this.


Wow:

While I waited I wrote my will and made an Advanced Directive. There was a question where you could specify what you’d want to happen to your body after you died. I never thought I’d care about such a thing—why would I? I’d be dead anyway. But when I really imagined it, I did care. I wanted to be buried in a Jewish cemetery, somewhere nearby so the people who cared about me could visit. I didn’t want to be forgotten.

But… none of that happened because the tumor shrank with chemo, and I went into remission. Then I fretted about finding a match on the bone marrow registry, but there she was—my little German angel. Then I worried she’d change her mind, or that the stem cells would get lost in transit (she donated her cells in Germany before they were couriered to Los Angeles).

I worried when I was admitted to the hospital while I got total body irradiation and high dose chemotherapy to eradicate my immune system and prepare me for transplant. I worried right up until I saw with my own eyes the bag of cells hanging off the IV pole as they were infused into my body. Now, I only had to wait and see if the cells took, or if a I developed a life-threatening infection, or if I got graft versus host disease, when the donor’s cells attack your own body, which can have serious consequences.

But… none of that happened, either. Sure, I felt like shit in the hospital, but I didn’t have any major complications and after a month I got to go home. I worried about infection but I didn’t get one. I wasn’t supposed to eat takeout but one day I was craving pizza so my mom and I ordered delivery and I ate the pizza and nothing bad happened (we did have to hide the pizza box evidence from my husband because he had an eagle eye on me to make sure I followed all the rules, which I found adorable. I’ve never seen someone use so much Purell in their life).


Her section on praying it away is really interesting


This is the first preventative medicine clinic in Los Angeles


This is a type of fish oil that usually comes from krill. It has a higher capacity to pass the blood-brain barrier of carriers of the APOE4 gene.


Guidelines | FAQ | Lists | API | Security | Legal | Apply to YC | Contact

Search: