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It would be really interesting if cars did this by default. Maybe it could figure out your threshold, how much of an outlier you are, and then you could opt-in to a new threshold that's somewhat better and/or closer to average.


Artificial is fine and playing word games for pedants is a trap.


Getting big "on a bender" vibes from Elon right now...


Some use cas9, such as dead cas9 (has endonuclease activity removed), and others do not.

Great interview where Dr. George Church talks base editing and CRISPR: https://www.foundmyfitness.com/episodes/george-church



That was two days ago, this is today.


At least in the case of the heart, there’s the beginnings of evidence that is suggestive of the fact that the damage is not simply incidental to systemic inflammation. https://medicine.wustl.edu/news/covid-19-can-kill-heart-musc...


That's interesting, thanks. But as you note, an in vitro study is still a long way from proof of claim -- just because something can happen does not mean that it does happen in actual people, and it certainly doesn't mean that it happens often. I would characterize this as evidence suggestive of a plausible mechanism.

One thing missing, for example, is why this doesn't appear to happen frequently. Most of the highly touted claims of cardiac involvement from summer 2020 have been debunked (e.g. in athletes).


Your point may be broadly true but subject to important caveats. Cancer is a very heterogeneous disease. There is evidence that _some_ cancers can use, for example, acetoacetate. https://www.sciencedaily.com/releases/2017/01/170112141359.h...


Wow, refreshing. To me, the most interesting part here is the incentive. It sounds like they ultimately just wanted to rise to the standard once it was made exhaustively clear. The important part here probably being that, by including peers, they know the feedback is coming from the right place, which is disarming.


Disarming is an excellent way to describe it. When the people who you feel that you're on par with point out that you're not pulling your weight, there's no place left for self delusion.


Might be inhibiting sirtuin activity... http://www.jbc.org/content/277/47/45099.short


What makes you think NMN has been "proven to be safe?" That's a pretty strong standard to conform to. There's virtually no clinical work that's been done at all, for starters.

A lot of genuine promising research in animals, but you also have this animal cancer model that suggests at least a little caution... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448588/


NMN is a B-vitamin derivative.


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