I'm with you 100%. I wish there was an OSS tool that was like Obsidian and cross-platform (no cloud hosting required). Logseq is the closest but the markdown standard isn't fully supported, and they add a lot of custom syntax/metadata.
Probably not what you're looking for, but I'm having a wonderful time running a private instance of Mediawiki. It's only accessible to me in my lan (or through my vpn). It's been my private digital garden for a few years now and i like it very much.
The only thing I truly miss is the possibility of pointing a Wikipedia-like app (might as well be the same codebase of the official wikipedia app, but pointing at my private endpoint).
I asked Claude 3 Opus about this, here is its response:
It's an interesting theory, but the relationship between diet and insulin resistance is more complex. Here's a breakdown:
The Randle Cycle:
The Randle Cycle, also known as the glucose-fatty acid cycle, suggests that high availability of fatty acids for beta-oxidation can inhibit glucose utilization.
This is because the products of fatty acid metabolism (acetyl-CoA and NADH) directly inhibit key enzymes involved in glucose metabolism, such as pyruvate dehydrogenase and phosphofructokinase.
High Sucrose and Carbohydrate Diet:
A diet high in sucrose and carbohydrates can lead to increased blood glucose levels, which in turn stimulates insulin secretion.
Chronically elevated insulin levels can lead to insulin resistance over time, as cells become less responsive to the effects of insulin.
Adapting to Glycolysis:
While minimizing beta-oxidation and relying primarily on glycolysis for energy might seem like a way to improve glucose metabolism, it's not that simple.
Excess glucose, if not utilized by cells or stored as glycogen, can be converted to fatty acids through de novo lipogenesis, contributing to increased fat storage and potential insulin resistance.
Insulin Resistance and Glucose Metabolism:
Insulin resistance is characterized by impaired glucose uptake and utilization by cells, leading to high blood glucose levels.
Poor glucose metabolism can indeed lead to a preference for beta-oxidation, as suggested by the Randle Cycle. However, this is a consequence of insulin resistance rather than a cause.
In conclusion, while the theory of adapting to glycolysis by minimizing beta-oxidation is interesting, a high sucrose and carbohydrate diet is more likely to contribute to insulin resistance rather than improve it. Insulin resistance is a complex metabolic disorder influenced by various factors, including diet, physical activity, and genetics.
There used to be themes like that but over time they became broken due to changes to the Firefox UI architecture changes. I would pay for a good userchrome.css that still worked to to implement a classic Netscape theme on modern firefox!
