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Grand Unified Theory:

Low intracellular ATP/GTP.

https://www.science.org/doi/10.1126/sciadv.adq6077


Nah, lithium is only treating something that is occurring much deeper: low glucose transport in the brain.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8772148/

This is why APoE e4 alleles are a risk factor, because they control glucose transport.

https://www.nature.com/articles/s41398-025-03550-w

The brain is just losing energy.


I would people need to read the #1 post on HN today to get a clue why they are failing with Alzheimer's.

https://www.scientificamerican.com/article/amateur-armed-wit...

Just like that math problem, we are starting off with wrong thinking right from the beginning. Some researchers are already talking about this but the plaques are actually a protective response to a metabolic problem in the brain which has to do with glucose transport.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8772148/

This is why people with dementia and Alzheimer's crave sweets so much:

https://helpdementia.com/why-dementia-patients-crave-sweets-...

Alzheimer's is not a neurological problem, it is a metabolic problem.


You may have naturally low dopamine production or release (or low ATP or GTP). Everyone will react differently because genetics so you are right, everyone needs to be mindful of their reaction.

You might want to look at this pathway, and the enzymes, and the cofactors for these enzymes:

https://www.researchgate.net/profile/Pingyuan-Gong/publicati...

Tyrosine 3-monooxygenase (TH) needs Iron

Aromatic-L-amino-acid decarboxylase (DDC) needs B6


Yes, same here. I have schizoaffective disorder and realizing that caffeine affected my mental health so drastically was the beginning of my recovery journey 30 years ago. I can use caffeine now as a drug when I need it. Same with alcohol.

Just because your heart rate is lower does it mean you’re any healthier however. This is just ridiculous measurement it means nothing.

The sauna might be acting like any other drug. There are a lot of drugs that will lower nighttime heart rate. Does that mean those drugs are healthier for you?


If your resting heart rate is lower without any drugs, it indicates that your heart can cause sufficient oxygen to be delivered to your organs with less effort than if it were higher. That can be caused by a variety of things (including stroke volume, capillary dilation and general obstruction (or not) of blood vessels). These are all good proxies for general health.

Drugs lowering your resting heart rate do not indicate this in the same way.


You think being n a Sauna is not a drug (effectively)?

No.

First, FISA was created in 1978 to protect Americans from the CIA by forcing them to show probably casuse. Section 702 of FISA is about intercepting any foreigners communications for which they need no warrent.

But the CIA incidentally collects data of U.S citizens during these warrentless wire taps, and that would be the 4th amendment challenge, but so far that is going nowhere.


Close but a lot of this, as Sen Wyden points out, turns on how NSA and DoJ lawyers define terms. So you get situations where bulk collection of communications of Americans to Americans into a data center isn't considered interception until a human looks at it. There's so much we don't know because the policies/legal interpretation and the FISA court rulings on them are secret. Sen Wyden tries to warn but he can only hint at the real dangers and policies

An important consideration is that just the graph of who talks to whom can be quite powerful:

https://kieranhealy.org/blog/archives/2013/06/09/using-metad...


There's also the game that they play where they spoof BGP announcements that cause routing changes for domestic traffic that makes it flow out and then back into the US, making it fair game for collection. Also, our Five Eyes partners aren't prohibited from collecting on US targets, and we all share.

Doesn't "receiving surveillance data about your citizens that your allies collected for you" also count as spying on your own citizens?

I'm not a lawyer but...

"You spied on me!" -"Relax, sweetheart... Of course I didn't spy on you. I got Mike to spy on you. Hey Mike!"


Unfortunately the lawyers did argue and it's legal. They really dug in to the wording and not the spirit of the law

Oh wow, that's crazy because people from the USA are always saying how unique and powerful the Constitution is and how many freedoms the USA has.

It seems almost like the USA is similar to other countries where the state does whatever they like. I bet that can't be true though surely because the USA has so many freedoms? You must be mistaken


> Don't create artificial scarcity.

Nah. You know what the answer is? Get to a mental and physical state where you need very little. Right now the only way to win is not to play.



Keep in mind that preëmptive pardons have not been upheld by the courts [1].

[1] https://www.criminallawlibraryblog.com/preemptive-pardons-co...


If that reached the supreme court however, precedent sadly might not matter too much.

we need to tax (update: sorry, not wealth) income.

90% tax on all income over $100 million. That would mean anyone making $500 million would still be bringing in $40 million a year. If you need more than $40 million a year you are just greedy and want to be some kind of king.

This would also mean the power of wealth would be neutralized.


This would have barely any actual effect since the number of people with such high income is nearly zero.

All it means is they would spend more on tax avoidance schemes which is wasteful.


I guess you think this high marginal tax rate would hold for unrealized capital gains? Otherwise your conclusion don't really hold.

Personally I prefer a wealth tax.


> 90% tax on all income over $100 million.

That's an income tax, not a wealth tax?


Yes, sorry.

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