I am disabled with Anxiety and Mood Disorder and chronic fatigue/depression. Typical "Bipolar" presentation. It runs in my family on my mothers side. We also have a history of early (45 years old) heart disease.
So I knew this was mitochondrial but it was revealed when I received my genome. We have issues with our electron transport chain; Complex I (ND1 and ND4) and Complex III (MT-CYB).
So diet and lifestyle was crucial in getting me off all of my meds, and I was on a lot. High dose riboflavin was a huge help.
Getting complex I to work well helps with the heart since it increases NAD. Also getting enough ubiquinone from diet helps. I get it mostly from seafood like Salmon and Liver. I might try and take a CoQ10 supplement soon. But the fact that we make it endogenously makes me think it is not needed. Statins will stop the production of CoQ10 by lowering FPPP production which is why they fail to help people with Heart Disease.
Balancing the flow and the oxidative stress from the mitochondrial electron transport chain is crucial.
Historically, yes 465 has been deprecated several years ago. But as many ISP and the largest email services kept using it, the IANA had to change its tune and 'resurrected' port 465 in this RFC.
It is funny: the RFC itself describes that as a wart, but reality is a harsh mistress.
Section 3-3 of RFC 8314 from 2018 has the details.
It's not much of a dilemma though, is it? Already-rich folks kowtowing to fascists for a quick buck is beyond pathetic.
US companies should stop targeting China for growth. If they don't steal your IP completely, they'll eventually freeze you out like they just did the NBA. It's happened to many companies and will eventually happen to you too. Play stupid games, win stupid prizes.
Back in the original dot-com bubble, I worked at a place that had the most amazing coffee machine I've ever seen. It was the size of a Coke machine and made ten thousand varieties of boutique coffee, most of which I'd never even heard of, all made to your specifications. It was incredible.
Then one day a guy came in with a hand cart, loaded the coffee machine on it, and rolled it away. A week later the layoffs started.
The lesson here isn't that there's something intangible or magic about free sodas or coffee. It's that when you used to give out free sodas and coffee, and then you stop, you're telling everyone in the company that business isn't as good as it used to be. Beverages are an easy thing for the bean-counters to get approval to cut, so when times get tough, they get cut first. But they're also a small line item, so while they're the first thing to get cut, they're usually not the last.
In other words, the free sodas are the proverbial canary in the coal mine. When they die, it's time to get out if you don't want to die with them.
This is why, when I visit clients these days, I make a point of going with them to their break room to get some coffee before our meeting starts. If their beverage situation has been upgraded since my last visit, they're doing well. If it's been downgraded, I know to be on guard for bean-counters coming after my relationship with them.
January 2001, ten weeks of chronic sinusitis turned to pneumonia. This was followed by sleeping 18-20 hours/day for about 3.5 months, plus twice-weekly doctors appointments while they called me crazy for fearing I might die while they ran more tests, stumped as to what was wrong with me.
In May, a sweat chloride test came back positive. The verdict: atypical cystic fibrosis.
I had already stopped being largely bedridden the month before in April. Many years of rehabilitation would follow.
Walking played a very large role in my recovery. At one point, I was homeless and my daily routine involved walking six to eight hours per day for some months.
The lymphatic system is a key part of this.
Lymphatic fluid is basically your blood stripped of red and white blood cells. While in your blood, it gets moved around by your heart.
But it doesn't stay in your blood vessels. Like water in the Earth's ecosystem, it isn't confined to the creeks and rivers of blood vessels. It seeps out into your tissues like groundwater, becoming interstitial fluid.
It carries nutrients with it to nourish your tissues as it flows out. It carries wastes with it as it flows back into your blood stream.
While out in your tissues, it is beyond the reach of your pumping heart. Its return trip is typically sluggish.
Unless you are in motion. Then your skeletal muscles fill in where your heart can't reach.
Interstitial fluid returns to your blood at several times it's normal rate when you are active. When, in a word, you exercise.
Walking helps your body take out the trash, a necessary element of the healing process largely overlooked by our current medical mental models where we think to add inputs in the form of drugs but mostly don't talk about throughputs.
I relate to this story personally. Wish you the best, and here are some resources that have helped me:
- after many failed attempts doing CBT and mindfulness based therapy, doing psychodynamic psychotherapy with a therapist who takes relationships and trauma seriously
- "Complex PTSD: From surviving to Thriving" (Pete Walker)
- "The Tao of Fully Feeling" (Pete Walker)
- "Treating Adult Survivors of Emotional Abuse and Neglect" (Hopper/Grossman/Spinazzola/Zucker)
- "Adult children of emotionally immature parents" (Gibson)
I’m part if that immigration wave, as well as my brother and a friend. Thankfully there was an opportunity to do that since we all worked in IT and employed for the same company that we helped to build remotely.
The political climate and economic instability, combined with knowledge of historical precedents makes me believe that Russian people’s future is very dim, as is their past over the whole life of that troubled country.
When we immigrated in 2012, I already had a son and as a father I couldn’t find it conscionable to state.
I didn’t want to be someone who decided to stay in Germany of 1935.
I found reading The Gifts of Imperfection (https://www.amazon.com/dp/B01N4KQI11), by Brene Brown, really helped reframe "imposter syndrome" for me.
“Perfectionism is not the same thing as striving to be your best. Perfectionism is the belief that if we live perfect, look perfect, and act perfect, we can minimize or avoid the pain of blame, judgement, and shame. It’s a shield. It’s a twenty-ton shield that we lug around thinking it will protect us when, in fact, it’s the thing that’s really preventing us from flight.”
You feel less like an imposter when you realise that nobody is perfect. You can embrace your imperfections and be satisfied with who you are today.
As a side note, this "Ask HN" question is one of the many reason I enjoy reading HN. It's a vulnerable question that has provoked several honest and thoughtful answers. It's not a "Top 10 way to overcome imposter syndrome" blog post...there's no link baiting or profit to be made. I suspect that asking the question will go along way to making the OP feel a lot better...it's tough to feel like an imposter when the response from the community is so positive.
Just because it has been an evolutionary advantage for our mind to be constantly active, doesn't mean that this can't change.
That's the point of evolution: we adapt to what's necessary and, for millions of years, constant thought was the factor that made us smarter than everyone else, and the humans in whom this didn't occur weren't smart enough, thus their genes disappeared from the gene pool.
This, however, doesn't mean we can't keep evolving towards a state of consciousness where constant thought isn't required, it just means that -- as is always the case -- existence is challenging, because there's millions of years of inertia behind the mind. It has a strong pull, because it was needed for survival. But we can keep evolving.
It doesn't need to continue like this forever. It just means that, as opposed to earlier, the people in whom thought is too strong and uncontrollable are now the ones whose genes are removed from the gene pool, through mental illness and anxiety.
If you're willing to spend some time watching your mind, you'll realize that it already stops all the time, it's just a matter of noticing this, thus strengthening its absence. But don't expect there to be a button to push to make it stop. It was needed for survival, so its cessation has become associated with fear. But, while you are conscious of this fact, it's not a problem, just a challenge.
> I am a minotaur and phoenix early adopter and moz before that
Interesting, I had never heard of Mozilla Minotaur before. I can't find many details online, other than it was a new mail client before Phoenix was renamed Firefox. Was Minotaur an early version of Thunderbird?
